Summary: Focus on explaining the difficulties in reducing malaria transmission in places like sub-Saharan Africa, I have chosen to discuss several papers that are somewhat dated now, but that provide a possible explanation for the difficulties confronting the global health community. It is hoped that these papers will provide an opportunity to introduce and discuss the underlying topics of pathogenesis, host/parasite interactions, immunity to parasitic infections, the dynamics of vector-borne diseases and disease intervention. I will also provide a description of the basic molecular and cellular biology of these parasites.
Suggested Readings: World Malaria Report 2019, World Health Organization Trape, J.-F., & Rogier, C. (1996). Combating malaria morbidity and mortality by reducing transmission. Parasitology Today, 12(6), 236–240. https://doi.org/10.1016/0169-4758(96)10015-6. Case Study: Aponte, J. J., Aide, P., Renom, M., Mandomando, I., Bassat, Q., Sacarlal, J., Manaca, M. N., Lafuente, S., Barbosa, A., Leach, A., Lievens, M., Vekemans, J., Sigauque, B., Dubois, M.-C., Demoitié, M.-A., Sillman, M., Savarese, B., McNeil, J. G., Macete, E., … Alonso, P. L. (2007). Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial. The Lancet, 370(9598), 1543–1551. https://doi.org/10.1016/s0140-6736(07)61542-6.
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